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What Does Gum Disease Have to Do With Erectile Dysfunction?

What Does Gum Disease Have to Do With Erectile Dysfunction?

2012-12-10

How can men avoid gumming up a relationship? They might start by brushing their teeth every day.

According to a new study in The Journal of Sexual Medicine, men with erectile dysfunction (ED) are three times more likely to have gum disease than men who do not have ED.

Turkish researchers found that 53% of the male patients with ED had severe gum disease (chronic periodontitis) compared with 23% who did not have ED. The study included 80 male patients with ED and 82 male patients without the condition; none were smokers since lighting up is considered a risk factor for both ED and gum disease. The study was also limited to those 30 years to 40 years old in an effort to rule out age as a risk factor. Even after accounting for age, body mass index (BMI), household income, and education status, the association between poor dental health and ED held.

“We think that it will be of benefit to consider periodontal disease as a causative clinical condition of ED in such patients,” the authors write.

What connects the two vastly different conditions? In a word, inflammation. Inflammation, which is the body’s immune response in action, may spread from the gums and harm other parts of the body. Gum disease is marked by bleeding of the gums and bone structure of teeth, and if left untreated, can cause tooth decay and tooth loss as immune cells launch an all-out attack on pathogens in the mouth. These bacteria can also seep into the bloodstream and damage blood vessels, and because erectile problems can be caused by impaired blood flow in the penis, poor dental hygiene can be associated with ED. About 150 million men worldwide suffer from erectile dysfunction, and nearly half of American adults over 30 (64 million) have periodontal disease — 56 percent of whom are men, according to the Centers for Disease Control and Prevention (CDC).

Continue reading What Does Gum Disease Have to Do With Erectile Dysfunction?

Ketamine for Depression: The Most Important Advance in Field in 50 Years?

Ketamine for Depression: The Most Important Advance in Field in 50 Years?

2012-10-09

In a new review in Science, the authors call the identification of the anesthetic and “club drug” ketamine as a rapid treatment for depression “arguably the most important discovery in half a century” of research on the condition
By Maia Szalavitz

In any given year, 7% of adults suffer from major depression, and at least 1 in 10 youth will reckon with the disorder at some point during their teenage years. But about 20% of these cases will not respond to current treatments; for those that do, relief may take weeks to months to come.

There is one treatment, however, that works much faster: the anesthetic and “club drug” ketamine. It takes effect within hours. A single dose of ketamine produces relief of depression that has been shown in studies to last for up to 10 days; it also appears to reduce symptoms of bipolar disorder and suicidal thoughts. Now, a new research review published in Science calls the discovery of these effects of ketamine, “”arguably the most important discovery in half a century” of depression research.

Ketamine doesn’t work the way traditional antidepressants do. Many such drugs affect levels of the neurotransmitter serotonin in the brain, and while the idea that depression is caused by low levels of serotonin or an “imbalance” of other key neurotransmitters has been firmly fixed in the popular imagination, scientists have known for decades that it can’t be that simple. For one, antidepressant drugs change the brain’s neurotransmitter levels immediately, yet depression doesn’t lift for several weeks, a delay that could be potentially deadly.

Another theory is that depression is caused not by neurotransmitter problems per se, but by damage to brain cells themselves in key regions critical to controlling mood. This idea fits nicely with evidence that stress can cause depression, since high levels of stress hormones can cause an overrelease of a neurotransmitter called glutamate, which damages cells and affects exactly the same suspected areas. More support for this theory comes from the fact that all known antidepressants increase cell growth in these areas too, providing an alternate explanation for their therapeutic results.

At first, ketamine seemed to throw a monkey wrench into that neat idea, however. It didn’t seem likely that a drug could repair cells within hours, but new research explored in a review paper in the journal Science suggests just that. Ketamine rapidly spurs the growth of new synapses, the connections between brain cells, and is associated with “reversal of the atrophy caused by chronic stress,” the authors write.

Unfortunately, the hallucinogenic and often outright unpleasant effects of ketamine mean that it can’t be used in the same way typical antidepressants are, and fears about its potential for misuse also hamper its development. Researchers are frantically trying to develop compounds that have the same effects as ketamine without producing a “high.”

In the meanwhile, however, ketamine is already FDA approved, so there’s nothing stopping psychiatrists from trying it and patients from asking for access to it in emergency situations when all else has failed. However, it must be given by infusion and carefully monitored (nasal sprays are being developed and there is an oral form that has some effects, but is not optimally absorbed), and the drug impairs patients for hours. Still, it relieves depression for at least several days: if there’s a choice between being entirely dysfunctional seven days a week or only out of commission for one or two, many people would accept that trade-off.

But while research on ketamine is ongoing, clinical use of the drug in the community remains rare. Fears about abuse continue to run high, though ketamine has never caught on as a major street drug. If the Science paper’s authors are right that ketamine’s effect on depression is a key advance — and if the drug really holds similar promise for bipolar disorder — patients might want to consider pushing for greater access. Ketamine is off patent, so no drug maker is likely to do so.

Maia Szalavitz is a health writer at TIME.com. Find her on Twitter at @maiasz. You can also continue the discussion on TIME Healthland’s Facebook page and on Twitter at @TIMEHealthland.

Study: Free Birth Control Slashes Abortion Rates

Study: Free Birth Control Slashes Abortion Rates

2012-10-08

By Olivia B. Waxman
What would happen if women at risk for unintended pregnancies received the birth control of their choice — especially the more effective kinds — at no cost?

The national abortion rate would plummet, according to a study conducted by researchers at the Washington University School of Medicine in St. Louis and published in the journal Obstetrics & Gynecology on Thursday.

The researchers enrolled 9,256 women from the St. Louis region into the Contraceptive Choice Project between August 2007 and September 2011. The women were aged 14 to 45, with an average age of 25, and many were poor and uninsured with low education. Nearly two-thirds had had an unintended pregnancy previously. Participants were either not using a reversible contraception method or willing to switch to a new one.

(LIST: 8 Preventive Health Services that Women Start Getting for Free Today)

Researchers provided free, FDA-approved birth control to the women for three years. The women were given their choice of contraception, including oral birth control pills and long-acting reversible contraceptive (LARC) methods like implants and IUDs. The researchers specially briefed the participants on the “superior effectiveness” of LARC methods — the T-shaped IUD, or intrauterine device, has close to 100% effectiveness and can last five to 10 years, for instance — and 75% of women chose those devices over the pill, patch or ring.

Over the course of the study, which lasted from 2008 to 2010, women experienced far fewer unintended pregnancies than expected: there were 4.4 to 7.5 abortions per 1,000 women in the study, after adjusting for age and race — much fewer than the national rate of 19.6 abortions per 1,000 women and lower also than the rate in the St. Louis area of 13.4 to 17 abortions per 1,000 women.

The effect of free contraception on the teen birth rate was remarkable: there were 6.3 births per 1,000 girls aged 15 to 19 in the study, compared with the national rate of 34.3 births per 1,000 teen girls.

(MORE: Which Birth Control Works Best? (Hint: It’s Not the Pill))

The findings come amidst contention over President Obama’s health-care law, which offers women FDA-approved birth control without a copay. As of August 1, contraception is covered for women signing up for new health insurance plans or renewing their existing plans.

“[C]hanges in contraceptive policy simulating the Contraceptive Choice Project would prevent as many as 41% to 71% of abortions performed annually in the United States,” the study’s authors wrote.

Nearly half of the more than 6 million pregnancies that occur each year are unintended, and about 43% of them end in abortion. Further, about 1 million births are unintended, costing U.S. taxpayers about $11 billion a year in associated expenses. Low-income women with less education are far more likely to have an unintended pregnancy than their wealthier, educated peers.

About half of unplanned pregnancies occur in women who are using no contraception; in other cases, women may be using short-acting contraception, like condoms or pills, which can fail if not used properly. In contrast, methods like IUDs, which are fitted into the uterus, or hormonal implants, which are surgically placed under the skin of the upper arm, can be placed and then forgotten about — no need to remember to refill a prescription or take a pill at the same time each day.

(MORE: What Got Lost in the Birth-Control Debate)

Women who choose long-acting contraception are more likely to stick with it as well: in the study, 85% were still using it a year later, compared with 35% of those choosing pills or other short-acting forms of birth control. “Because LARC methods have been shown to have higher continuation rates than other reversible methods, the number of adolescents and women using no contraception would decline, further decreasing the unintended pregnancy rate,” the authors conclude.

Yet American women use LARC methods at far lower rates than in other countries. In large part, that’s because of cost: upfront costs to implant an IUD, which requires a doctor visit, can total $500 to $1,000, for example. Over a decade, however, birth control pills can cost just as much. American doctors also tend not to recommend long-acting birth control to women as often as they do the pill or patch, though IUDs and implants may be up to 20 times more effective.

That’s why the American College of Obstetricians and Gynecologists is now urging doctors to recommend IUDs and implants as “first-line” contraceptive choices to their teen patients.

When sex is a pain in the back.

When sex is a pain in the back.

2012-10-01

By Ian Kerner, Special to CNN
September 6, 2012
An estimated eight out of 10 Americans will suffer from back pain at some point in their lives, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. It’s no surprise that can have big effects on what goes on in your bedroom: whether a temporary strain slows you down or a more serious injury halts sex altogether.

We don’t have good statistics on the number of people who eschew sex because of back pain, mainly because many people don’t like to talk about sex with their doctors. But it stands to reason that back troubles can make sex a pain, too.

“Being in pain can make it more difficult to concentrate on pleasurable sensations, which in turn can make it more difficult to become aroused and have an orgasm,” explains Florida-based sex therapist Rachel Needles. “Depending on the dose and type, pain medication can also interfere with arousal and orgasm in both men and women.”

Fortunately, there are steps you can take to deal with the situation. Here are some ways to enjoy intimacy without back pain:
Talk about it. Back pain can be tricky because people often look fine, even if they feel terrible. That’s all the more reason to keep your partner in the loop.

“The most important thing is to be open with your partner and have ongoing discussions about how the pain is interfering with sexual intimacy,” says Needle. “This will help the partner in pain to not just avoid sex, but instead to team up with their partner to find ways for sex to be more comfortable and enjoyable.”

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Work it out. Dr. Maureen O’Leary, a specialist in orthopaedic injuries and neuromusculoskeletal impairments, guides clients through exercises designed to stretch and strengthen muscles.

“I’m also a big fan of Pilates, which is very effective at strengthening the muscles in the abdomen and torso that help support the back,” she says.

Yoga may help, too: “I personally have recurrent lower back issues and have found that practicing yoga several times a week, especially right before sex, helps tremendously,” says sex and marriage therapist Shellie M. Selove.

An experienced instructor, personal trainer or physical therapist can explain specific exercises and stretches that target the area of your back that’s problematic.

Make adjustments. It makes sense that, depending on the location of your pain, some sexual positions will be more and less comfortable than others. “People with lower back problems like sciatica or a herniated disc tend to feel more pain when bending forward, while those with spinal stenosis may find bending backward to be more painful,” explains O’Leary.

Let your body be your guide. If lying on your back hurts, you may want to be on top during sex, or vice versa. Side-by-side or spooning positions can take pressure off the back.

Experiment by placing a pillow under your lower back, stomach, knees or neck to see if the extra support helps, or try an angled pillow to make certain positions more comfortable, suggests sex educator Stephanie Mitelman.

Are you too tired for sex?

Explore other forms of intimacy. “It’s so important to touch and be touched by your partner,” says Needles. Taking a hot bath or shower or getting a massage can help loosen tense muscles before sex.

Even better, they can be fun, connecting forms of foreplay: Treat your partner to a soapy shower, or trade gentle massages to get in the mood. If intercourse seems like it might be too painful, make foreplay the main attraction, or focus on other forms of intimacy, such as cuddling, kissing, oral or manual stimulation, or simply sharing a fantasy.

Most causes of back pain eventually resolve with time and proper care. Whether you choose to make some adjustments in the bedroom or decide to make rest your priority, there’s no need to banish intimacy altogether. Take this opportunity to connect and communicate with your partner — inside the bedroom and out.

Stay-at-home dads are sexy

Do Sports Products Really Enhance Your Workout? Maybe Not

Do Sports Products Really Enhance Your Workout? Maybe Not

2012-07-27

Do sports drinks really give your workout an extra edge? A recent study of the performance-enhancing claims of more than 100 fitness products says probably not. In fact, of the hundreds of such claims identified in product advertisements and websites, researchers couldn’t find a single one that was backed by solid scientific evidence.

For the study, researchers at the University of Oxford looked at advertisements for sports drinks, oral supplements, footwear, clothing and fitness devices like wristbands and compression sleeves in 100 general interest magazines and the top 10 sport and fitness magazines in the U.K. and the U.S. The team also searched the websites of any product making claims to enhance athletic performance or improve recovery, seeking references for scientific studies supporting these claims.

Continue reading Do Sports Products Really Enhance Your Workout? Maybe Not

Smoking mothers’ embryos ‘grow more slowly

Smoking mothers’ embryos ‘grow more slowly

2012-07-10

Time-lapse photography has shown that embryos of smoking women develop more slowly.

French academics in an IVF clinic took regular pictures of an egg from the moment it was fertilised until it was ready to be implanted into the mother.

At all stages of development, embryos from smokers were consistently a couple of hours behind, a study showed.

The lead researcher, from Nantes University Hospital, said: “You want a baby, quit smoking”.

Smoking is known to reduce the chances of having a child. It is why some hospitals in the UK ask couples to give up smoking before they are given fertility treatment.

As eggs fertilised through IVF initially develop in the laboratory before being implanted, it gave doctors a unique opportunity to film the embryos as they divide into more and more cells.
Slow start

Researchers watched 868 embryos develop – 139 from smokers.

n the clinic the embryos of non-smokers reached the five-cell stage after 49 hours. In the smokers it took 50 hours. The eight-cell stage took 62 hours in smokers’ embryos, while non-smokers’ embryos reached that point after 58 hours.

Senior embryologist and lead researcher, Dr Thomas Freour, told the BBC: “Embryos from smoking women, they behave slower, there is a delay in their development.

“On average it is about two hours, it is significant and nobody knew that before.”

This study cannot say what impact the slower development has, or if this affected the chances of having a child.

Dr Freour speculated that “if they go slower, maybe something is starting to go wrong and they wouldn’t implant.”

His advice was simple: “You should quit smoking, it couldn’t be easier. What else can I say? You want a baby, quit smoking.”

Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield, said it was an “interesting” study which pioneered the use of new technology.

“It uses a fancy piece of equipment called an embryoscope which allows scientists to watch in real time how embryos develop without disturbing them.

“It’s early days for this machine but we need trials like this to test its potential, we know our current methods of embryo selection are based on what looks good down the microscope to a trained eye.”

The findings were presented at the European Society for Human Reproduction and Embryology (ESHRE) meeting in Turkey.

A New Treatment For Curved Penis?

A New Treatment For Curved Penis?

2012-06-11

About 5% of men are plagued with a distressing condition called Peyronie’s disease — a painful curvature of the penis during erection that can make sex difficult or even impossible.

This week, a drug company promised them some relief: in trials, a drug called Xiaflex reduced the curvature significantly compared with placebo, and also helped men feel less troubled about their condition.

In one trial, average curvature went from 48.8 degrees to 31 degrees in a year, a 37.6 improvement, compared with a change from 49 degrees to 39 degrees in the placebo group, a 21.3% improvement. The treatment is no cure, but “it’s a major advantage over what we have now, which is nothing,” researcher Dr. Culley C. Carson III, a professor of urology at the University of North Carolina, told the New York Times.

If the drug is approved to treat Peyronie’s, it would be marketed to the estimated 65,000 to 120,000 American men who receive the diagnosis each year. Xiaflex’s maker, Auxilium Pharmaceuticals, said that approximately 5,000 to 6,500 of these men are currently treated with injectable therapies or surgery.

(MORE: Could the ‘Cuddle Chemical’ Oxytocin Improve Male Sexual Function?)

Xiaflex was approved in 2010 as treatment for Dupuytren’s contracture, a condition that causes fingers to remain clenched. Xiaflex is an enzyme called collagenase, which breaks down collagen, a key component of the connective tissue found in various organs, including the skin, tendons and cartilage. Both Dupuytren’s and Peyronie’s are caused by an excess of collagen that builds up in the hand or penis.

In Peyronie’s, the collagen contributes to plaques that cause the bent shape. Treatment could involve up to eight injections of Xiaflex into the plaque over a period of months; doctors would also help break up the plaque by hand. Side effects may include pain, swelling and clotted blood within the tissue. Auxilium hopes the treatment will be preferable to surgery — which can cause erectile dysfunction — for many men and doctors.

“Obtaining a statistically significant reduction in penile curvature deformity and improvement in Peyronie’s disease bother without the risks of surgical intervention represents an enormous advantage for eligible patients suffering from Peyronie’s disease,” Dr. Larry Lipshultz, professor of urology and chief of the division of male reproductive medicine and surgery at Baylor College of Medicine, said in a Auxilium statement.

(MORE: Add Inches!! (No, Really, Men Can Make It Longer))

Auxilium plans to file a supplemental Biologics License Application with the Food and Drug Administration within the year seeking approval for Xiaflex to treat Peyronie’s disease.

Read more: http://healthland.time.com/2012/06/08/a-new-treatment-for-curved-penis/#ixzz1xTD4KrRz

Which Birth Control Works Best? (Hint: It’s Not the Pill)

Which Birth Control Works Best? (Hint: It’s Not the Pill)

2012-06-07

Long-lasting contraceptives such as the intrauterine device (IUD) and implants are better at preventing pregnancy than more popular birth control methods, including the pill, patch and vaginal rings, a new study concludes.

The study involved 7,486 women participating in the Contraceptive Choice Project, run by researchers at Washington University School of Medicine in St. Louis. The women, aged 14 to 45, were given their choice of contraception for free and then tracked for up to three years for unintended pregnancy. The results, published in the New England Journal of Medicine, found that longer-lasting contraceptives were up to 20 times more effective — that is, women using IUDs, implants or hormone injections were up to 20 times less likely to get pregnant — after three years than the shorter-acting methods of birth control.

(MORE: Plan B: 1 in 5 Pharmacists May Deny Eligible Teens Access to Emergency Contraception)

Among the 1,500 women who chose to use birth control pills, patches or vaginal rings, 4.8% became pregnant after one year, compared with only 0.3% of the nearly 5,800 women who chose IUDs or implantable contraceptives. After three years, 9.4% of women using short-acting contraceptives got pregnant, compared with 0.9% of those using longer-acting methods.

Women using hormone injections (a minority at 176) had even better success, with 0.1% becoming pregnant after one year and 0.7% becoming pregnant after three years.

The results, while striking, aren’t all that surprising, considering that shorter term options depend on consistent compliance to work most effectively: pills must be take daily and patches and rings must be replaced within days or weeks.

In contrast, IUDs, which are fitted into the uterus, last five or 10 years, depending on the device. Hormonal implants, which are surgically placed under the skin of the upper arm, are effective for three years. And injections last three months.

(MORE: The Pill at 50: Sex, Freedom and Paradox)

How well a birth-control method worked depended also on the age of the user: younger women, under 21, using pills, patches or vaginal rings were nearly twice as likely to become pregnant as older women who used the same contraceptives. Why? Because they were more likely to forget to take their pills or to change their patch or ring. There were no age-related differences in pregnancy rates among women using IUDs, implants or injections.

Overall, poorer women with less education were also more likely to experience contraceptive failures.

The researchers hope their results will prompt more women to consider using long-acting contraceptives to prevent unwanted pregnancy. Each year in the U.S., there are an estimated 3 million unplanned pregnancies, about 1.2 million of which lead to abortion, according to the study. About half of unintended pregnancies occur because of because of incorrect or inconsistent use of contraception, including condoms and birth-control pills.

Still, the pill is the most commonly used contraceptive in the U.S. That may be because women don’t hear about long-acting methods as often as other contraceptives, or because women are more comfortable taking a pill or using a patch than having a device implanted in their body. Another factor: cost. IUDs and implants are expensive and aren’t typically covered by insurance.

(MORE: Teen Sex Ed: Instead of Promoting Promiscuity, It Delays First Sex)

“Nationally, only about 5 percent are using long-lasting methods like IUDs and implants. We know one of the barriers to why they’re not using them more frequently is up-front costs,” the study’s lead author, Dr. Brooke Winner of Washington University School of Medicine, told Reuters. “If [more] women were using these products nationally, there would be a very significant drop in unintended pregnancies, which would have far-reaching effects.”

While longer-lasting contraceptives can be more expensive up front, they may turn out to cost about the same as the pill when the expense is broken down by day, the researchers noted. IUDs and implants can be removed when women wish to become pregnant, and fertility typically returns immediately.

The researchers hope their study will also encourage doctors to consider IUDs and implants when discussing birth control with their patients. “If there were a drug for cancer, heart disease or diabetes that was 20 times more effective we would recommend it first,” another study author, Dr. Jeffrey Peipert, a professor of obstetrics and gynecology at Washington University, told the Wall Street Journal.

Alice Park is a writer at TIME. Find her on Twitter at @aliceparkny. You can also continue the discussion on TIME’s Facebook page and on Twitter at @TIME.

Read more: http://healthland.time.com/2012/05/24/iuds-and-implants-beat-the-pill-in-preventing-pregnancy/?iid=hl-main-feature#ixzz1x5mUfmlM

Is Mom’s Lack of Vitamin D in Pregnancy Linked with Child’s Weight? By Alexandra Sifferlin | @acsifferlin | May 23, 2012

Is Mom’s Lack of Vitamin D in Pregnancy Linked with Child’s Weight? By Alexandra Sifferlin | @acsifferlin | May 23, 2012

2012-05-24

Maintaining good health during pregnancy is one of the surest ways mothers can protect their developing babies’ well-being. A new study suggests that adequate levels of vitamin D could be one such protective factor.

Some data have linked low vitamin D levels to weight gain and obesity in women and children, but in the new study researchers at the University of Southampton in the U.K. found that association may begin the womb: children born to mothers with low levels of the vitamin during pregnancy had more body fat at age 6 than those whose mothers weren’t vitamin deficient.

The study, published in the American Journal of Clinical Nutrition, looked at the vitamin D levels of 977 pregnant women and the body composition of their kids. All the women were part of the Southampton Women’s Survey — one of the largest women’s surveys in the U.K.

Continue reading Is Mom’s Lack of Vitamin D in Pregnancy Linked with Child’s Weight? By Alexandra Sifferlin | @acsifferlin | May 23, 2012

New book questions ‘The Myth of Sex Addiction’

New book questions ‘The Myth of Sex Addiction’

2012-03-30

Is sex addiction for real? Or is it “nothing more than a pop-psychology phenomenon, serving only to demonize sex, enforce moral views of sex and relationships and excuse irresponsible behaviors?”

Those are the fighting words of psychologist David Ley, who, in his rousing new book, “The Myth of Sex Addiction,” expresses concern over the slippery ease with which America’s mainstream media and burgeoning “addictionology industry” have seemingly conspired to transform a debatable diagnosis into a foregone conclusion.

“There are real dangers inherent in the sex addiction concept,” Ley writes. “I believe that for the field of health care, medicine, and mental health to endorse and reify a flawed concept creates a very dangerous slippery slope of moral relativism, where any socially unacceptable behavior is labeled a mental disorder subject to psychiatric treatment.”

Continue reading New book questions ‘The Myth of Sex Addiction’